Andrographis paniculata extract 10–50% andrographolide powder

Andrographis paniculata Extract 10–50% Andrographolides

Andrographis paniculata extract is produced from the aerial parts, primarily leaves and stems, of Andrographis paniculata (Burm.f.) Wall. ex Nees, a member of the Acanthaceae family. The concentrated botanical powder contains characteristic labdane-type diterpene lactones and is commercially standardized using andrographolide as the principal analytical marker.

Essencefield supplies this extract within a 10–50% andrographolide range, including established 10% and 50% HPLC grades. Different assay levels allow formulators to balance botanical-extract loading, target marker concentration, capsule or tablet space, sensory contribution, and overall formulation density.

Ingredient Profile & Common Uses

The commercial ingredient is derived from the aerial portions of A. paniculata, principally leaf and stem material. Extraction concentrates its characteristic diterpene-lactone fraction before the material is dried and milled into powder. This distinguishes the product from simple herb powder and from highly purified andrographolide, which represents a separate phytochemical ingredient rather than a conventional botanical extract.

Assay level determines how much material is required to reach a defined marker target. A 10% grade provides a less concentrated extract matrix for conventional botanical formulations, while a 50% grade delivers five times the marker concentration per unit weight. Higher-assay material can therefore reduce formula loading when capsule fill weight, tablet mass, or premix concentration is limited.

A pronounced bitter profile is one of the ingredient’s most important formulation characteristics. The principal diterpene lactone also has poor aqueous solubility, making dry dosage forms comparatively straightforward while creating additional challenges in water-based systems. Formulators should consider taste masking, wetting, dispersion, sedimentation, and visual stability when developing non-dry formats.

Application Areas

Hard Capsules

The extract is well suited to capsule formulations where a defined HPLC assay supports accurate ingredient loading and consistent marker control within concentrated botanical products.

Coated Tablets

Tablet formulations can use different assay levels according to marker targets and available tablet mass. Film coating may also help reduce direct exposure to the ingredient’s strong bitter taste.

Multi-Botanical Blends

The ingredient can be incorporated into botanical complexes that require a defined phytochemical marker rather than relying only on a raw herb powder or extract-ratio declaration.

Powdered Premixes & Sachets

Concentrated grades can reduce botanical mass in dry premixes and powdered supplements. Premixing and blend uniformity become increasingly important as inclusion levels decrease.

Typical Specifications

Specification	Information
Product Name	Andrographis paniculata Extract
Botanical Name	Andrographis paniculata (Burm.f.) Wall. ex Nees
Botanical Family	Acanthaceae
Plant Part	Aerial Parts — Leaf & Stem
Ingredient Type	Standardized Botanical Extract
Product Form	Extract Powder
Active Marker	Andrographolide
Standardization Range	10–50% Andrographolide
Primary Commercial Grade	10% Andrographolide
High-Assay Grade	50% Andrographolide
Assay Method	HPLC
Identification	Chromatographic / botanical identity testing
10% Grade Appearance	Yellow-brown powder
50% Grade Appearance	Tan to brown powder
Sensory Profile	Characteristically bitter
Characteristic Chemical Class	Labdane-type diterpene lactones

Marker Compounds & Standardization

Andrographolide is the principal marker associated with Andrographis paniculata extracts and belongs to the labdane diterpene-lactone family. The botanical also contains related constituents including neoandrographolide, andrograpanin, and 14-deoxy-11,12-didehydroandrographolide, forming part of its characteristic phytochemical profile.

An individual andrographolide assay should not be confused with specifications expressed as total andrographolides or total diterpene lactones. These terms can represent different analytical definitions, so procurement documents and analytical reports should use a clearly defined analyte basis.

Assay percentage should also be distinguished from extract ratio. A 10:1 extract describes the relationship between botanical raw material and finished extract, whereas an andrographolide specification defines the measured concentration of the marker compound.

Technical & Quality Considerations

Analytical evaluation should begin with botanical identity and the defined marker assay. HPLC provides quantitative control of the principal compound and chromatographic separation from related constituents, making it useful for differentiating a controlled extract from non-standardized botanical material. Botanical authentication and chromatographic evaluation together provide a stronger basis for raw-material qualification.

Physical characteristics change as the extract becomes more concentrated. Lower-assay material is typically darker, while the higher-assay grade is lighter tan to brown. Strong bitterness remains relevant across formulations, and the poorly water-soluble diterpene-lactone fraction can limit complete dissolution. These properties influence dosage-form selection, sensory design, and dispersion strategy.

For capsule, tablet, and dry-blend scale-up, R&D teams should evaluate powder flow, premixing sequence, blend uniformity, compression behavior, and fill-weight contribution. Lower inclusion levels in concentrated formulations increase the importance of homogeneous distribution. For aqueous or semi-aqueous systems, development work should focus on wetting, dispersion, settling, haze, redispersibility, and taste masking rather than targeting complete dissolution.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.