Angelica Pubescens Extract 5–30% Total Coumarins

The roots of Angelica pubescens, the hairy-stemmed angelica known as du huo in Chinese herbal practice, provide the starting material for this extract, which does not draw on the qiang huo root of Notopterygium that is often paired with it in traditional formulas. Ethanol extraction concentrates the coumarins of the root, and the liquor is dried to a light brown powder.

The primary grade is 30% total coumarins by UV, with 5% as the lower end of the range. The powder is 80 mesh and insoluble in water. The 30% grade serves capsules and softgels with a small fill weight, while the 5% grade suits dry compounds that keep more of the aromatic root matrix.

SKU: BOT-STX-0097 Category: Standardized Extracts Tags: Ethanol Extracted, Polyphenols, Pubescent Angelica, Root & Rhizome, Softgels & Oil Fills, Standardized Extracts

Coumarin Standardization & Grades

Pubescent angelica root holds a mixed coumarin fraction: angular dihydrofuranocoumarins such as columbianadin and columbianetin, linear furanocoumarins such as bergapten and xanthotoxin, and simple coumarins such as osthole. The grade sums the class without naming one compound, because the root carries all three types. The botanical entity is Angelica pubescens Maxim., and the part used is the root.

Grade	Assay & Method	Where It Fits
5% Total Coumarins	UV	Dry compounds keeping the root matrix
30% Total Coumarins	UV	Capsules and softgels with small fill

Grade choice follows dose, fill weight and the amount of aromatic root matrix a formula should keep. The 30% grade carries six times the coumarin load per gram of the 5% grade, so a capsule reaches its target in a smaller fill. The 5% grade retains the essential oil fragments, starch and polysaccharides of the root, which makes it bulkier, paler and more aromatic. Siblings from the same root are the unstandardized Angelica Pubescens Root Extract Powder and the milled Angelica Pubescens Root Powder.

Two secondary markers, osthole and columbianadin, are recorded in the data and are described here without numbers. Buyers who compare quotes should note that a UV class total and an HPLC value for a named coumarin are different measurements, and the first is always larger than the second.

The common name needs care. The Chinese drug du huo and the Japanese drug of the same character are related but come from different species and varieties, and the angelicas of the Chinese pharmacopoeia, namely dahurica, pubescens and sinensis, are distinct drugs with separate profiles. A botanical name and the root as the stated part keep the identity clear.

Coumarin Analysis & Purity Risks

Both grades are measured by UV, a spectrophotometric method that reads the coumarin class at a characteristic absorption maximum after the sample has been dissolved in an alcohol and diluted into range. The reading is calibrated against a reference coumarin, so the choice of reference changes the number. An HPLC result for osthole is a different measurement and cannot be converted into the UV total.

The method is not exclusive to coumarins. Chromones, some flavonoids and conjugated pigments absorb near the same wavelength, so a dark or poorly cleaned sample can read high. For that reason, the UV figure is best read together with a chromatographic fingerprint that shows which coumarins are actually present.

The fingerprint of du huo has columbianadin and columbianetin as prominent peaks, with osthole, bergapten and xanthotoxin among the minor ones. Angular coumarins can isomerize under acid, and the ratio between columbianetin and its glycoside depends on handling, so a shifted ratio indicates how the root was dried and extracted.

Purity risks follow from the botany. Several roots are sold under the name du huo, including those of Heracleum species in some markets, and they carry different coumarin patterns. The aerial parts of the plant are not used. Identity is better protected by a species statement, the root as the stated part and a chromatographic profile than by a total percentage.

Typical Specifications

Specification Item	Product Information
Latin Name	Angelica pubescens
Plant Part	Root & Rhizome
Processing	Ethanol Extraction
Compound Class	Coumarins, Polyphenols
Common Name	Pubescent Angelica, Du Huo
Ingredient Type	Standardized Extract
Marker Compound(s)	Total coumarins (dihydrofuranocoumarins, furanocoumarins and osthole of Angelica pubescens root)
Primary Grade	30% Total Coumarins (UV)
Available Grades	5% · 30% Total Coumarins (UV)
Appearance	Light Brown powder
Solubility / Dispersibility	Insoluble in Water
Quality Parameters
Moisture (LOD)	≤5.0%
Total Ash	≤5.0%
Particle Size	80 mesh
Heavy Metals	Lead ≤2 ppm · Arsenic ≤1 ppm · Cadmium ≤1 ppm · Mercury ≤0.1 ppm
Microbiology	TPC ≤1,000 cfu/g · Yeast & Mold ≤100 cfu/g · E. coli Negative · Salmonella Negative/25 g
Shelf Life	24 months in unopened original packaging, cool and dry storage

Applications by Grade

30% Grade for Compact Capsules

The 30% grade supplies a coumarin target in a small capsule fill. The light brown powder is fine and slightly sticky, so a flow agent and a dry filling room keep the hopper feeding evenly, and weight checks should start each production run.

30% Grade for Oil-Based Fills

Coumarins dissolve in oils far better than in water, so softgel fills disperse the 30% grade in a carrier oil. Mill the Angelica pubescens powder fine and stir throughout encapsulation, since the particles are insoluble and settle in the feed line.

5% Grade for Dry Herbal Compounds

At 5% the extract is dosed by weight in dry compounds, where the root’s warm, aromatic character sits beside other root and rhizome powders. Pre-mix it with a bulking agent, and screen the blend before filling to remove small lumps.

5% Grade for Tablet Blends

Tablets of the lower grade compress with some elasticity because of the starch, and the aromatic volatile fraction can stick to punches. Use a dry binder and an absorbent, and run a compression trial with a hardness check after storage.

30% Grade for Granule Premixes

Granules carry the high grade with a binder and a flavor system, where citrus or ginger covers the bitter, pungent edge of the root. Wet the insoluble powder evenly to avoid specks of concentrate, and check the granule for flow after drying.

Technical & Quality Considerations

The Angelica pubescens extract is a light brown powder with a warm, aromatic and slightly sweet odor and a bitter, mildly pungent taste. The powder does not dissolve in water, so in a drink base it forms a loose, fine sediment. Coumarins dissolve in ethanol, in oils and in some surfactant systems, and the choice of carrier decides how they behave in a finished product.

Coumarins are stable in dry form, though furanocoumarins degrade under ultraviolet light, so protect the powder and any clear-packaged finished product from light. Strong alkali opens the lactone ring of coumarins reversibly, which changes the UV spectrum and the reading. At production scale, handle the Angelica pubescens extract in a ventilated station and pre-mix it with a portion of the carrier.

Aromatic residues linger on equipment, so wash with warm detergent or an ethanol cleaner and dedicate scoops where possible. Compare each lot with a retained sample for color, odor and flow, record the date the drum was opened and store the drum closed, cool and away from light, apart from delicate flavors that can pick up its odor.

An Angelica pubescens extract is checked by its odor and by its columbianadin-led fingerprint. The aroma is warm and slightly sweet, and a sharply different smell suggests a different species. Keep a retained sample of each Angelica pubescens extract lot, and compare the columbianadin and osthole peaks of later lots with it, because the ratio between them is a quick signal of species and handling.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.