Bacoside Standardization & Grades
Bacosides are dammarane-type triterpene saponins, in which a four-ring triterpene skeleton carries sugar chains. The two aglycones most often named are jujubogenin and pseudojujubogenin. Bacosides are a mixture, so a percentage names a group of related saponins that were summed, not one compound. They are the standardization target because they are the characteristic saponins of the herb. The botanical entity is Bacopa monnieri (L.) Pennell, a plant of wet ground in the Plantaginaceae, and the part used is the aerial herb.
| Grade | Assay & Method | Where It Fits |
|---|---|---|
| 20% Bacosides | HPLC | Drink mixes and broad-profile capsules |
| 50% Bacosides | HPLC | Compact capsules and tablets |
The two grades differ in concentration and in the matrix around the marker. The 50% grade is a saponin concentrate that supplies a marker dose from a small fill. Bacopa monnieri extract at 50% is therefore the more concentrated and more bitter choice, and Bacopa monnieri at 20% is the easier one to flavor. The 20% grade carries more of the sugars, flavonoids and other solids of the herb, so Bacopa monnieri extract at this level is lighter in bitterness and easier to flavor. The same plant is also supplied as a 10:1 ratio extract, the Bacopa Monnieri Extract Powder, and as a milled herb, the Brahmi (Bacopa monnieri) Powder. The name brahmi also refers to Centella asiatica in some regions, which is a different plant with different markers.












