Apigenin 98%

Apigenin 98% is a high-assay flavone ingredient produced from Matricaria chamomilla L. flowers through extraction, concentration, purification, drying, and milling. The finished material concentrates apigenin, the 4′,5,7-trihydroxyflavone aglycone naturally present in chamomile and other botanical sources, into a chemically defined phytochemical ingredient.

Essencefield supplies a ≥98% grade measured by HPLC for supplement development, dry-dose formulations, premixes, and other projects requiring controlled flavone content. Its high assay allows comparatively low inclusion levels, while limited aqueous solubility makes particle distribution, blend uniformity, wetting, and finished-product format important considerations during formulation.

SKU: BOT-PHY-0017 Categories: Phytochemicals, Flavonoids Tags: Antioxidant Support, Apigenin, Dietary Supplements, Flavones, Flavonoids

Ingredient Profile & Common Uses

Produced from Matricaria chamomilla L. flower, this purified material differs from conventional chamomile powder and broad-spectrum extracts. Its defining constituent is the flavone aglycone apigenin, C15H10O5, rather than an extract ratio or a general total-flavonoid value. Purification therefore produces a much more chemically defined ingredient than botanical materials retaining a broad spectrum of native plant constituents.

The principal commercial grade contains ≥98% apigenin by HPLC. Buyers source this material according to compound assay and chromatographic identity rather than traditional extract ratio or total-flavonoid standardization. The concentrated specification is particularly relevant where formulators need a defined quantity of one phytochemical while minimizing the additional plant solids associated with less purified botanical extracts.

The high-assay powder is primarily suited to concentrated nutraceutical, botanical-active, and dry formulation systems. Its yellow coloration and hydrophobic character can influence appearance, wetting, and dispersion, while the relatively low inclusion level requires attention to powder distribution. Premixing or geometric dilution can therefore be useful before the ingredient is incorporated into a larger production blend.

Application Areas

Capsules

The concentrated grade can be incorporated into capsule formulations requiring controlled flavone content. Development should evaluate powder flow, fill-weight consistency, particle compatibility, and distribution within the finished blend.

Tablets

Tablet formulations should consider excipient compatibility, compression behavior, blend uniformity, and dissolution performance when incorporating this high-assay phytochemical into direct-compression or granulated systems.

Dry Powder Premixes

Intermediate premixing or geometric dilution can improve distribution when a small amount of the ingredient must be dispersed consistently through a substantially larger powder mass.

Stick Packs & Sachets

Dry sachet systems can incorporate the powder where formulators account for flow, segregation, visible color contribution, taste, and compatibility with the other powdered ingredients.

Solubility-Enhanced Formulation Development

Projects requiring improved aqueous performance may investigate micronization, dispersion systems, lipid-based approaches, cyclodextrin complexes, or other delivery technologies designed to improve wetting and dissolution.

Typical Specifications

Parameter	Specification / Reference
Product Name	Apigenin 98%
Botanical Source	Matricaria chamomilla L.
Plant Part	Flower
Active Compound	Apigenin
Chemical Name	4′,5,7-Trihydroxyflavone
Systematic Name	5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
CAS Number	520-36-5
EC Number	208-292-3
UNII	7V515PI7F6
PubChem CID	5280443
Molecular Formula	C15H10O5
Molecular Weight	270.24 g/mol
Chemical Class	Flavone
Ingredient Type	High-purity phytochemical
Primary Specification	Apigenin ≥98.0%
Analytical Method	HPLC
Processing	Extraction · Concentration · Purification · Drying · Milling
Physical Description	Pale yellow to beige powder
Water Behavior	Very low aqueous solubility
Reference Melting Point	345–350°C

Compound Identity & Purity

Apigenin is a flavone characterized by hydroxyl substitution at the 4′, 5, and 7 positions. The compound has the molecular formula C15H10O5 and a molecular weight of 270.24 g/mol. Its aglycone structure distinguishes it from naturally occurring apigenin glycosides and from broader flavonoid mixtures found in less purified botanical materials.

For a 98% grade, HPLC provides compound-specific separation and quantification. This analytical approach allows the target flavone to be distinguished from structurally related constituents and makes purity more meaningful to procurement and quality teams than an extract ratio or nonspecific total-flavonoid result.

This distinction is also commercially important. A purified single-marker ingredient is purchased and formulated according to compound concentration, whereas conventional botanical extracts are commonly evaluated through extract ratio, multi-constituent profiles, or broader marker systems. These materials should therefore not be treated as interchangeable specifications.

Technical & Quality Considerations

HPLC assay and chromatographic identity are the central analytical controls for the high-purity grade. Incoming quality evaluation should verify the target peak and assess the chromatographic profile rather than relying only on a nonspecific flavonoid test. This provides a more relevant basis for raw-material qualification, repeat-order comparison, and supplier consistency.

The compound is very poorly soluble in water. Published experimental work has reported equilibrium solubility as low as the low-microgram-per-milliliter range in aqueous buffer, explaining why direct addition to water may produce incomplete dissolution, visible particles, precipitation, or sedimentation. Particle characteristics and wetting behavior can therefore affect practical performance even when chemical assay remains unchanged.

For capsule, tablet, sachet, and premix production, R&D teams should evaluate flow, particle distribution, segregation risk, and content uniformity. Geometric dilution or an intermediate premix can help when the ingredient represents a small percentage of the final formulation. Bench-scale mixing should also be compared with pilot-scale processing because powder movement and segregation can change as batch size, equipment geometry, and handling conditions increase.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.