Bisdemethoxycurcumin 98%

Bisdemethoxycurcumin 98% is a high-purity curcuminoid phytochemical commonly abbreviated as BDMC and also known as Curcumin III, Didemethoxycurcumin, and Bisdesmethoxycurcumin. Its chemical identity is (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione, with the molecular formula C19H16O4 and molecular weight 308.33 g/mol.

The 98% grade is the primary commercial specification for purified BDMC. HPLC is widely used in the market for purity determination, while the final assay method, appearance range, storage conditions, and batch-release criteria for Essencefield material are defined by the approved product specification and lot-specific COA.

SKU: BOT-PHY-0001 Categories: Phytochemicals, Lignans, Quinones & Specialty Phytochemicals Tags: Antioxidant Support, Bisdemethoxycurcumin, Curcuminoids, Diarylheptanoids, Dietary Supplements

Curcuminoid Profile & Common Uses

BDMC is structurally related to curcumin and demethoxycurcumin but contains no methoxy groups on either aromatic ring. This structural distinction gives it an independent chromatographic and physicochemical profile. Purified BDMC should therefore be distinguished from turmeric extract, total curcuminoids, and Curcumin 95%, which contain different distributions of individual curcuminoids.

The 98% grade is selected when compound-level identity and purity are more important than the broader botanical matrix. Typical purchasing requirements include analytical method development, curcuminoid profiling, botanical quality evaluation, phytochemical research, reference-material work, and specialized formulation development.

Analytical & Formulation Applications

Analytical Method Development

Suitable for HPLC and related chromatographic workflows requiring defined BDMC identity, including method development, retention-time comparison, purity evaluation, and quantitative analysis.

Curcuminoid Profiling & Quality Control

Used to distinguish BDMC from curcumin and demethoxycurcumin when evaluating turmeric-derived extracts, curcuminoid preparations, botanical raw materials, and analytical samples.

Phytochemical Research

Provides a defined high-purity compound for natural-product characterization, comparative curcuminoid studies, structure-specific evaluation, and other laboratory programs requiring isolated BDMC.

Specialty Formulation R&D

Can be evaluated in formulations requiring a defined curcuminoid, with particular attention to aqueous insolubility, dispersion, premixing, precipitation, carrier selection, and content uniformity.

Typical Specifications

Parameter	Specification / Reference Property
Product Name	Bisdemethoxycurcumin 98%
Compound Name	Bisdemethoxycurcumin
Abbreviation	BDMC
Common Synonyms	Curcumin III · Didemethoxycurcumin · Bisdesmethoxycurcumin
IUPAC Name	(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
CAS Number	33171-05-0
Alternative CAS	24939-16-0
Molecular Formula	C19H16O4
Molecular Weight	308.33 g/mol
Commercial Grade	98%
Common Market Assay Method	HPLC
Physical State	Solid
Reference Appearance	Yellow to orange crystalline powder
Chemical Class	Curcuminoid · Diarylheptanoid · Polyphenol · β-Diketone
Water Solubility	Practically insoluble in water
Reference Organic Solvent Behavior	Soluble in DMSO; limited solubility reported in ethanol
Reference UV λmax	419 nm

Both 33171-05-0 and 24939-16-0 are associated with Bisdemethoxycurcumin in established chemical databases and commercial catalogs. The primary CAS used for an Essencefield lot should follow its approved commercial documentation.

Compound Identity & Purity

Bisdemethoxycurcumin belongs to the diarylheptanoid curcuminoid family and contains phenolic hydroxyl groups together with a β-diketone system. Compared with curcumin and demethoxycurcumin, the absence of aromatic methoxy substitution provides a clear structural basis for its separate chemical and analytical identity.

A 98% purity grade is widely established in the commercial market, with HPLC commonly used to evaluate purity. Sigma lists ≥98% by HPLC, while TCI offers >98% material with HPLC and titration specifications. This supports 98% HPLC as an important buyer search term, although the analytical method published as an Essencefield release specification should still match the actual COA.

The product is therefore best positioned as an isolated phytochemical, rather than as turmeric extract or a mixed curcuminoid preparation. This distinction is important for procurement teams comparing assay, identity, analytical method, and formulation requirements.

Analytical & Formulation Considerations

Identity and purity control require adequate chromatographic selectivity because curcumin, demethoxycurcumin, and BDMC are closely related compounds. HPLC is widely used for commercial purity assessment, while complementary techniques such as UV/DAD, mass spectrometry, IR, or NMR may support identity work depending on the analytical program. Reference melting data also vary by method and material: Wako reports 213–217°C, while TCI reports approximately 224°C with decomposition, so melting behavior is better treated as a characterization property than a universal batch-release range.

BDMC is practically insoluble in water but shows substantially greater solubility in polar organic solvents such as DMSO. Exact solvent-solubility values vary with material and test conditions; Cayman reports solubility in DMSO, DMF, and ethanol, while other suppliers publish different DMSO values. For analytical and formulation work, standardized solvent selection and sample preparation are therefore more useful than applying a single universal solubility number.

For formulation development, R&D teams should evaluate premixing, dispersion, carrier selection, precipitation risk, processing conditions, and content uniformity. These factors become particularly important at low inclusion levels or in liquid systems where the compound’s limited aqueous solubility can influence dissolution and physical stability.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.