Magnolol 98%

Magnolol is a purified botanical phytochemical associated with the bark of Magnolia officinalis. Chemically, it belongs to the biphenyl-type neolignan family. The commercial ingredient is positioned as a defined high-purity compound rather than whole magnolia bark powder, a conventional ratio extract, or a multi-component Magnolia bark extract.

Essencefield supplies Magnolol 98% with magnolol specified at ≥98.0% by HPLC. This high-assay grade provides a defined individual-analyte ingredient for formulation, R&D, supplier qualification, and commercial sourcing projects where controlled magnolol content is required rather than an unspecified total Magnolia phenol or combined-neolignan value.

SKU: BOT-PHY-0214 Categories: Phytochemicals, Lignans, Quinones & Specialty Phytochemicals Tags: Dietary Supplements, Lignans, Magnolol, Neolignans, Phenylpropanoids

Ingredient Profile & Common Uses

Magnolol, CAS 528-43-8, occurs naturally in Magnolia officinalis bark and is chemically identified as 5,5′-diallyl-2,2′-dihydroxybiphenyl. Unlike conventional bark powders and ratio extracts, the purified ingredient is commercially defined by the concentration of one target phytochemical. This distinction makes it more appropriate for projects requiring a chemically characterized Magnolia-derived active rather than the broader constituent profile of a botanical extract.

Commercial grade selection centers on individual magnolol purity and the analytical method used to quantify it. The ≥98% HPLC grade is distinct from Honokiol 98% and from specifications based on combined magnolol and honokiol. For purchasing and QA teams, this distinction is important because products described broadly as “Magnolia phenols” may represent different analyte compositions even when their headline percentage appears similar.

The high-assay material is used in concentrated botanical-active development, dietary supplement formulation, cosmetic and personal-care R&D, and specialty premixes. Its low aqueous solubility and lipophilic character make carrier selection, wetting, dispersion, blend uniformity, and precipitation control more relevant to formulation development than the extraction-ratio parameters normally used for conventional botanical extracts.

Application Areas

Dietary Supplement Formulation

Used in concentrated botanical-active and phytochemical formulations where developers require a defined magnolol input instead of the variable constituent profile of conventional Magnolia bark extract.

Cosmetic & Personal-Care Development

Suitable for development in emulsions, lipid-containing systems, and related cosmetic formats where a chemically defined Magnolia-derived phytochemical can be incorporated into an appropriate delivery phase.

Botanical Active Premixes

The concentrated material can be incorporated into premixes for downstream formulation. Low inclusion levels make geometric dilution, carrier compatibility, and homogeneous distribution important during blending.

R&D and Ingredient Evaluation

A defined single-compound specification supports formulation screening, supplier comparison, compatibility studies, chromatographic evaluation, and development work requiring controlled phytochemical identity and purity.

Typical Specifications

Item	Specification / Reference Information
Product Name	Magnolol 98%
Ingredient Type	Purified botanical phytochemical
Botanical Source	Magnolia officinalis
Source Material	Bark
Primary Specification	≥98.0% Magnolol
Analytical Method	HPLC
CAS Number	528-43-8
Molecular Formula	C18H18O2
Molecular Weight	266.3 g/mol
Chemical Class	Biphenyl-type neolignan
EC Number	610-903-7
PubChem CID	72300
Chemical Synonym	5,5′-Diallyl-2,2′-dihydroxybiphenyl
Reference Melting Point	101.5–102°C
Reference XLogP3-AA	5.0
Water Behavior	Low aqueous solubility

Compound Identity & Purity

The 98% specification refers to the concentration of the individual magnolol analyte rather than total Magnolia phenols or total neolignans. This distinction is commercially important because a percentage value alone does not establish which compound or combination of compounds has been quantified.

Magnolol and honokiol share the molecular formula C18H18O2 and the same nominal molecular weight but differ in substitution pattern. Chromatographic separation is therefore required to distinguish the target compound from its structural isomer and other related Magnolia constituents.

HPLC serves both as the principal assay method and as an important identity and purity-control tool for the high-assay grade. For procurement and quality evaluation, a clearly defined individual-analyte specification provides greater chemical precision than a nonspecific total-phenol or combined-neolignan statement.

Technical & Quality Considerations

Analytical evaluation should prioritize identity, individual-analyte assay, and chromatographic resolution. The HPLC profile should distinguish the target peak from related Magnolia neolignans rather than rely only on a broad total-phenol measurement. For this ingredient, chromatographic specificity is more informative than generic botanical-extract parameters because purity is defined at the individual-compound level.

The compound has low aqueous solubility and a reference XLogP of approximately 5.0, consistent with relatively lipophilic behavior. Direct addition to water should not be treated as equivalent to producing a true solution. Formulation development should instead evaluate appropriate carriers, co-solvents, lipid phases, emulsification systems, or other delivery approaches suitable for the intended finished-product format.

Scale-up should focus on uniform distribution and physical compatibility. Low-inclusion dry blends may benefit from premixing or geometric dilution before the active enters the final batch. In liquid or semi-solid systems, developers should evaluate wetting, dissolution or dispersion, crystallization, precipitation, and physical stability under the actual processing and storage conditions used for the finished formulation.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.