Berberine HCl 98% HPLC yellow crystalline powder

Berberine 98%

Berberine 98% is a high-purity protoberberine alkaloid ingredient. Berberine occurs naturally in several botanical genera, including Coptis and Berberis, while concentrated commercial material is commonly supplied as the chloride salt, widely known in ingredient markets as Berberine Hydrochloride or Berberine HCl.

The 98% grade is a common high-assay specification, with 97% and 98% grades both established in commercial supply and HPLC widely used for assay. The material is typically supplied as a yellow crystalline powder. For procurement and QA, the selected specification should clearly define chemical form, analytical method, and assay reporting basis.

SKU: BOT-PHY-0005 Categories: Phytochemicals, Alkaloids Tags: Alkaloids, Berberine, Isoquinoline Alkaloids, Metabolic Support, Protoberberine Alkaloids

Ingredient Profile & Common Uses

Berberine belongs to the protoberberine group of isoquinoline alkaloids. High-purity material differs substantially from whole Coptis, Phellodendron, or Berberis powders and from multi-component botanical extracts because the commercial identity is centered on a purified individual alkaloid rather than a broad botanical constituent profile. Botanical or manufacturing origin should therefore be confirmed from the selected specification rather than inferred from the ingredient name.

Commercial grade selection is driven primarily by assay and chemical form. Current markets commonly offer 97% and 98% grades, with 98% HPLC representing a principal high-assay sourcing specification. The chloride form corresponds to CAS 633-65-8. Buyers should also confirm whether assay results are expressed as received, on a dried basis, or on an anhydrous basis where this distinction affects specification interpretation.

High-purity berberine is used mainly in concentrated dietary supplement, nutraceutical, and functional formulation projects requiring a defined alkaloid assay rather than a broad botanical profile. The ingredient has an intense yellow appearance and pronounced bitter character. Limited aqueous solubility means that dissolution, precipitation, color contribution, taste masking, and distribution within the finished matrix should be evaluated during development.

Application Areas

Capsules & Tablets

A common format for concentrated berberine formulations because encapsulation or tableting helps manage the ingredient’s strong yellow color and bitterness. Powder flow, compression behavior, and content uniformity should be evaluated using the selected grade.

Powder Blends & Premixes

Suitable for dry supplement blends and premixes where a defined high-assay phytochemical is required. Appropriate premixing helps support consistent distribution of the concentrated ingredient across larger formulation batches.

Drink Powders & Dispersible Systems

Use in drink powders, suspensions, and other dispersible systems requires evaluation of wetting, dissolution, precipitation, visible yellow coloration, and bitterness. Performance may vary with concentration, temperature, and formulation matrix.

Typical Specifications

Parameter	Commercial / Reference Information
Product Name	Berberine 98%
Common Commercial Identity	Berberine Hydrochloride / Berberine Chloride
Ingredient Type	Purified protoberberine alkaloid
Chemical Class	Quaternary protoberberine isoquinoline alkaloid
Primary Specification	98%
Primary Market Grades	97% / 98%
Common Assay Method	HPLC
CAS Number — Chloride Form	633-65-8
Molecular Formula — Chloride Form	C₂₀H₁₈ClNO₄
Molecular Weight — Chloride Form	371.82 g/mol
Appearance	Yellow to light-yellow crystalline powder
Reference Aqueous Solubility	Approximately 1.96 mg/mL in water at 25°C

Reference chemical identity and aqueous-solubility values describe the chloride form and should not be interpreted as batch-release specifications. Product-specific physical and quality parameters are confirmed against the applicable commercial specification.

Compound Identity & Purity

The commercial chloride form belongs to the quaternary protoberberine alkaloid family. For high-purity grades, precise chemical-form definition matters because hydration state and assay basis can influence how analytical results are interpreted. Hydrated chloride forms also exist, so projects requiring precise stoichiometric or analytical interpretation should verify the specified form and reporting basis.

A 98% material is a purified phytochemical rather than a standardized botanical extract containing berberine within a broader constituent matrix. Berberine-containing botanicals may also contain related alkaloids such as palmatine, coptisine, and jatrorrhizine. Chromatographic evaluation can therefore help distinguish the principal berberine component from related compounds associated with botanical source and purification profile.

Purity should be considered together with chromatographic identity rather than treated as an isolated number. For qualification work, the analytical method, reference standard, impurity profile, and applicable assay basis provide more useful information than the nominal grade alone.

Technical & Quality Considerations

HPLC is the primary analytical approach for confirming assay and chromatographic purity in high-assay material. Incoming qualification should review chemical identity, reference standard, reporting basis, and relevant related-alkaloid limits where applicable. Botanical source or manufacturing origin should be treated as a separate purchasing attribute when required rather than inferred from CAS number or assay.

The ingredient is characteristically yellow and strongly bitter. Published data indicate limited aqueous solubility, with dissolution behavior affected by temperature and formulation environment. These characteristics are particularly relevant in products where visible color, taste, precipitation, or incomplete dissolution may affect finished-product quality.

For capsules, tablets, and dry blends, development should evaluate premixing, content uniformity, powder flow, filling or compression behavior, and visual color effects. Dispersible systems require additional testing of wetting, dissolved concentration, precipitation during storage, matrix effects, and bitterness management. Scale-up should use the same approved grade evaluated during formulation whenever practical.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.