Demethoxycurcumin 98%

Demethoxycurcumin, abbreviated DMC and also known as Curcumin II or desmethoxycurcumin, is a naturally occurring curcuminoid associated with Curcuma longa rhizome. It is a diarylheptanoid polyphenol and β-diketone with the molecular formula C20H18O5. Its single aromatic methoxy substitution distinguishes it chemically from related turmeric curcuminoids.

Essencefield supplies Demethoxycurcumin at ≥98% purity by HPLC as a high-purity phytochemical compound. This grade is intended for buyers requiring a defined DMC analyte rather than a turmeric extract standardized to total curcuminoids. Its compound-specific purity supports analytical method development, natural-product characterization, comparative research, and formulation R&D.

SKU: BOT-PHY-0003 Categories: Phytochemicals, Lignans, Quinones & Specialty Phytochemicals Tags: Antioxidant Support, Curcuminoids, Demethoxycurcumin, Diarylheptanoids, Dietary Supplements

Ingredient Profile & Common Uses

Demethoxycurcumin is one of the characteristic phytochemicals naturally associated with turmeric rhizome. It is chemically distinct from curcumin and bisdemethoxycurcumin through its single aromatic methoxy substitution. The 98% product is therefore positioned as a purified individual compound rather than turmeric powder, a broad botanical extract, or a mixed curcuminoid ingredient.

Commercial sourcing centers on high-purity material identified and quantified chromatographically. ≥98% by HPLC represents the principal commercial specification for this product. For procurement and analytical teams, the key distinction is that the assay measures demethoxycurcumin itself rather than the combined concentration of several structurally related compounds in a standardized turmeric extract.

The compound has strong intrinsic coloration and very limited aqueous solubility. These characteristics influence wetting, dispersion, solvent selection, and precipitation behavior during formulation work. It is particularly relevant to analytical, natural-product, comparative phytochemical, and delivery-system projects where researchers require a defined single compound rather than a complex botanical matrix.

Application Areas

HPLC Method Development & Chromatographic Analysis

High-purity material can support chromatographic method development where laboratories need to separate and quantify demethoxycurcumin independently from curcumin, bisdemethoxycurcumin, and related turmeric constituents.

Curcuminoid Comparative Research

The purified compound supports studies comparing structurally related turmeric constituents on the basis of chromatographic behavior, stability, solubility, and other physicochemical characteristics.

Natural Product Characterization

Demethoxycurcumin can be used in the identification, profiling, and characterization of individual phytochemicals associated with Curcuma species and curcuminoid-containing botanical materials.

Formulation & Delivery-System R&D

Its low aqueous solubility makes the compound relevant to research involving carriers, premixing, dispersion, solvent systems, encapsulation approaches, and delivery strategies for hydrophobic phytochemicals.

Typical Specifications

Parameter	Specification / Reference Property
Product Name	Demethoxycurcumin 98%
Common Abbreviation	DMC
Common Synonyms	Curcumin II · Desmethoxycurcumin · Monodemethoxycurcumin
Chemical Name	(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
CAS Number	22608-11-3
PubChem CID	5469424
UNII	W2F8059T80
InChIKey	HJTVQHVGMGKONQ-LUZURFALSA-N
Molecular Formula	C20H18O5
Molecular Weight	338.35 g/mol
Chemical Class	Curcuminoid · Diarylheptanoid · Polyphenol · β-Diketone
Ingredient Type	High-purity phytochemical compound
Product Form	Powder
Primary Specification	≥98% Demethoxycurcumin
Analytical Method	HPLC
Botanical Association	Naturally occurring curcuminoid associated with Curcuma longa rhizome

Compound Identity & Purity

Demethoxycurcumin has the molecular formula C20H18O5 and a molecular weight of 338.35 g/mol. Its defined (1E,6E) identity is associated with CAS 22608-11-3, PubChem CID 5469424, and UNII W2F8059T80. Curcumin II, desmethoxycurcumin, and monodemethoxycurcumin are established naming variants for the compound.

Structurally, curcumin contains two aromatic methoxy groups, demethoxycurcumin contains one, and bisdemethoxycurcumin contains none. These differences create distinct chemical entities and chromatographic profiles, which is important when sourcing an individual high-purity compound rather than a mixed turmeric-derived fraction.

For the 98% grade, HPLC is the primary analytical basis for purity determination. Chromatographic separation allows the target analyte to be evaluated independently from related constituents and provides more meaningful procurement information than a general declaration of total curcuminoid concentration.

Technical & Quality Considerations

Analytical evaluation should prioritize compound identity together with compound-specific HPLC purity. The method should adequately distinguish the target analyte from curcumin, bisdemethoxycurcumin, and other closely related peaks rather than reporting them collectively. Peak resolution and the presence of closely eluting components are therefore relevant when reviewing chromatographic data for a high-purity material.

The compound is strongly colored and has very limited water solubility. Published physicochemical data show substantially greater compatibility with selected organic solvents than with water, making solvent environment important during analytical and formulation work. Wetting, apparent dissolution, precipitation, color distribution, and physical stability can change significantly with the selected delivery system.

For dry formulations, premixing should be evaluated when the material represents a low proportion of the total blend so that distribution remains uniform before further processing. In liquid or dispersed research systems, R&D teams should assess wetting, carrier selection, solvent compatibility, precipitation, and sedimentation. Water-based systems generally require an appropriate dispersion or delivery approach rather than direct dissolution.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.