Dihydromyricetin (DHM) 98%

Dihydromyricetin (DHM), also known as ampelopsin, is a naturally occurring flavanonol widely associated with vine tea. The high-purity material is supplied as a compound-defined phytochemical powder rather than a conventional broad-spectrum botanical extract, giving formulators and procurement teams a specific chemical ingredient for dietary supplement and specialty formulation projects.

Essencefield supplies Dihydromyricetin 98%, with ≥98% DHM by HPLC as the primary commercial specification. The compound has CAS No. 27200-12-0, molecular formula C15H12O8, and molecular weight 320.25 g/mol. Its high assay supports concentrated formulations, while limited aqueous solubility and sensitivity to processing conditions are relevant during product development.

SKU: BOT-PHY-0123 Categories: Phytochemicals, Flavonoids Tags: Antioxidant Support, DHM, Dietary Supplements, Dihydromyricetin (DHM), Flavonoids

Ingredient Profile & Common Uses

Dihydromyricetin is a polyhydroxylated flavanonol also known as ampelopsin. It occurs prominently in vine tea, whose currently accepted botanical name is Nekemias grossedentata; Ampelopsis grossedentata remains a widely used botanical synonym in scientific literature and ingredient trade. Unlike vine tea powder or a lower-assay extract, this material is commercially defined by the concentration of the individual phytochemical.

For commercial sourcing, ≥98% by HPLC represents the principal high-purity grade. This specification differs from extract-ratio products and total-flavonoid extracts because procurement is based on direct quantification of dihydromyricetin rather than the concentration of a broader botanical fraction. The result is a more clearly defined ingredient entity for formulation, supplier comparison, and analytical evaluation.

The concentrated material is especially suited to dry dosage forms and other formulations requiring a defined DHM input at relatively low inclusion weight. Its limited water solubility affects the transition from capsules or powder blends into aqueous systems, where wetting, dispersion, precipitation, pH, thermal exposure, and processing time become more important development variables.

Application Areas

Capsules & Tablets

The high-assay grade supports concentrated capsule and tablet formulas where a defined phytochemical input is required without introducing large quantities of accompanying botanical solids.

Stick Packs & Powder Blends

The powder can be incorporated into sachets, stick packs, and multi-ingredient dry blends. Appropriate premixing helps support uniform distribution when the inclusion level is low.

Multi-Ingredient Supplement Formulas

Dihydromyricetin can be combined with botanical extracts, vitamins, minerals, amino acids, and specialty ingredients where a compound-defined input is preferred over a broad vine tea extract profile.

Liquid Formulations Requiring Solubility Management

The purified material is not inherently water-soluble. Aqueous concentrates, shots, suspensions, and related formats require evaluation of wetting, solubilization or suspension strategy, precipitation, pH, and processing temperature.

Typical Specifications

Parameter	Specification / Reference
Product Name	Dihydromyricetin (DHM) 98%
Compound Name	Dihydromyricetin
Common Synonym	Ampelopsin
Ingredient Type	High-Purity Phytochemical
Chemical Class	Flavanonol / Dihydroflavonol
Product Form	Powder
Primary Specification	≥98% Dihydromyricetin
Analytical Method	HPLC
CAS Number	27200-12-0
Molecular Formula	C15H12O8
Molecular Weight	320.25 g/mol
Botanical Association	Vine tea
Accepted Vine Tea Name	Nekemias grossedentata
Commercial Botanical Synonym	Ampelopsis grossedentata
Published Aqueous Solubility	Approx. 0.2 mg/mL at 25°C
Solvent Behavior	Greater solubility in ethanol than in room-temperature water

Compound Identity & Purity

Dihydromyricetin belongs to the flavanonol, or dihydroflavonol, subclass of flavonoids and contains multiple hydroxyl groups across its flavonoid structure. This chemical profile distinguishes it from broader botanical fractions containing multiple flavonoids and other plant constituents. In high-purity form, the compound itself rather than an extract ratio defines the ingredient identity.

The hydroxylated molecular structure does not result in high room-temperature water solubility. Published data place aqueous solubility at approximately 0.2 mg/mL at 25°C, while solubility is higher in ethanol-containing systems and at elevated temperatures. These properties are particularly relevant when selecting between dry dosage formats and liquid delivery systems.

Dihydromyricetin also contains stereochemical centers. Conventional purity HPLC establishes compound content but does not automatically characterize stereochemical composition. Where optical identity is important to a development or research program, chiral chromatography, optical rotation, or another suitable stereochemical method represents a separate analytical evaluation.

Technical & Quality Considerations

Analytical evaluation of the high-purity material should establish chromatographic identity and quantitative assay of dihydromyricetin. Routine HPLC addresses compound content, while stereochemical characterization requires a separate chiral method when relevant to the project. This distinction is useful when comparing conventional purity data with materials supported by optical-rotation or chiral chromatographic information.

Physical behavior becomes especially important in aqueous formulation. Published data indicate limited water solubility at room temperature, while increasing temperature can improve dissolution but may also affect chemical stability. Dihydromyricetin is generally more stable under acidic conditions than under alkaline conditions, and increasing pH and temperature can accelerate degradation.

Scale-up should therefore be matched to dosage form. Dry systems should be evaluated for premixing, blend uniformity, flow, capsule filling, and compression behavior. Liquid systems require additional assessment of wetting, dissolution or suspension, precipitation, pH, and thermal history. Research on stereochemical stability also indicates that processing above approximately 80°C warrants additional evaluation because elevated temperatures can accelerate racemization.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.