Alisol C 98%

Within the group of Alisma triterpenoids, alisol C is the most oxidized free alcohol, with two ketones, one hydroxyl at carbon 11 and an epoxide in the side chain. It is isolated from the rhizome of Alisma orientale by ethanol extraction and purification as a white, water-insoluble powder.

The Primary Grade is 98% alisol C by HPLC, in Food / Dietary Supplement Grade. The figure describes the free alcohol, not its 23-acetate, and the CAS number and InChIKey in the table apply to the alcohol. Acetylated alisols are separate products.

SKU: BOT-PHY-0061 Category: Phytochemicals Tags: Alisma, Ethanol Extracted, Plant Compounds, Root & Rhizome, Softgels & Oil Fills, Terpenoids

Alisol C Chemical Identity

Alisol C (C30H46O5, molecular weight 486.7) has a ketone at carbon 3, a second ketone at carbon 16 conjugated with a ring D double bond, a hydroxyl at carbon 11 and a side chain that ends in a dimethyloxirane. Its 23-acetate has the formula C32H48O6. Compared with alisol B (C30H48O4) the molecule has one more oxygen and two fewer hydrogens, which reflects the extra ketone.

Alisol C is the least abundant and the most oxidized of the three main alisol alcohols, so it is the one most likely to be mistaken for alisol B in a name-based search. The CAS number 30489-27-1 and the InChIKey in the table fix the compound.

The source is the rhizome of Alisma orientale (Sam.) Juz., which current checklists treat as a synonym of Alisma plantago-aquatica; the trade name is retained. Related products are Alisol C 23-Acetate 98%, Alisma rhizome powder.

Because alisol C is minor in the rhizome, requests for it often arrive with the wrong name. Alisol C and alisol C 23-acetate have different CAS numbers (30489-27-1 and 26575-93-9), different molecular weights (486.7 and 528.7) and different polarity, and the specification should quote both identifiers.

Typical Specifications

Specification Item	Product Information
Natural Source	Alisma orientale rhizome
Plant Part	Root & Rhizome
Processing	Ethanol Extraction & Purification
Compound Class	Terpenoids
Chemical Name (IUPAC)	(5R,8S,9S,10S,11S,14R)-17-[(2R,4S)-4-[(2R)-3,3-dimethyloxiran-2-yl]-4-hydroxybutan-2-yl]-11-hydroxy-4,4,8,10,14-pentamethyl-2,5,6,7,9,11,12,15-octahydro-1H-cyclopenta[a]phenanthrene-3,16-dione
CAS Number	30489-27-1
Molecular Formula	C30H46O5
Molecular Weight	486.7 g/mol
PubChem CID	101306923
InChIKey	DORJGGFFCMZTHW-KXVAGGRESA-N
Purity	98% (HPLC)
Grade	Food / Dietary Supplement Grade
Appearance	White powder
Solubility / Dispersibility	Insoluble in Water
Quality Parameters
Moisture (LOD)	≤5.0%
Total Ash	≤5.0%
Heavy Metals	Lead ≤2 ppm · Arsenic ≤1 ppm · Cadmium ≤1 ppm · Mercury ≤0.1 ppm
Microbiology	TPC ≤1,000 cfu/g · Yeast & Mold ≤100 cfu/g · E. coli Negative · Salmonella Negative/25 g
Shelf Life	24 months in unopened original packaging, cool and dry storage

Alisol C Purity & Related Substances

Alisol C 98% is a single-compound grade measured by HPLC. The figure is the share of the alisol C peak in the chromatogram, with water, ash and non-absorbing material outside it. The conjugated enone absorbs ultraviolet light more strongly than the saturated protostane skeletons, so a detector set near the enone maximum is practical, and the wavelength should be stated.

The related substances are alisol C 23-acetate, alisol B and its 23-acetate, alisol A and other minor oxidized alisols. Alisol C is more polar than the acetate and elutes earlier on reversed-phase columns. Oxidation or hydrolysis during storage can add minor peaks, so a retest of an older lot is sensible.

It is a plant-derived compound taken from the rhizome by ethanol extraction followed by purification. A total alisol value from an extract cannot stand in for this single-compound purity, and neither can a figure for the acetate.

Release uses a clean chromatogram, a diode-array check against the enone spectrum and a low water level. The ratio of alisol C to its acetate in the same lot gives a view of how much ester is present, and a lot of the free alcohol should show only a small acetate peak.

A further caution concerns the response factor. If an alisol C chromatogram is read at a wavelength tuned to the enone, neighboring alisols that lack the enone give small peaks and the purity is over-stated. Reading the trace at a second, low wavelength shows whether such non-enone impurities are present.

For the reduced analogue without the second ketone, Alisol B 98% is the closest alcohol.

Alisol C Solubility & Delivery

Alisol C is insoluble in water. The two ketones and the single free hydroxyl add some polarity, but the protostane skeleton keeps the molecule lipophilic. It dissolves in ethanol, methanol and other organic solvents and in lipid phases, and it forms a white suspension in water.

The conjugated enone and the epoxide control the formulation window. Neutral conditions protect both, while strong acid opens the ring and strong alkali attacks the enone. Delivery approaches in principle include oil-phase dispersions, anhydrous co-solvent premixes, phospholipid complexes and micronized powders.

The dry powder is stable when closed, but light and moisture should be limited. A dilution premix with a neutral carrier improves weighing accuracy, and containers are closed quickly after use. Cleaning between products is checked visually because traces of white powder are hard to see on stainless steel.

In practice alisol C is dosed at very low weights, so premixing in two or three dilution steps is typical. Each step is checked for uniformity, and the final premix is blended into the bulk. Static control reduces loss on surfaces, and the work is done in low light.

Application Areas

Hard capsules with neutral carriers

Alisol C is premixed with a neutral excipient and filled in a dry room. Acidic or alkaline partners are avoided, and the capsules are packed in opaque containers with a desiccant to keep light and water away from the enone.

Softgel oil-phase fills

Dispersing alisol C in an oil with a surfactant gives a stable softgel fill without free water. The tank is stirred and the fill is sampled for uniformity during encapsulation, so each softgel carries the same dose.

Tablets with coating

Tablets use neutral fillers and are coated to limit humidity and light. A content uniformity check on a sample from the run confirms that the very small dose is spread evenly through the compressed units.

Powder sticks with dispersants

Dry sticks use a dispersant to hold the insoluble powder in suspension, and foil packaging gives a light barrier for the enone. The finished drink is kept near neutral pH, and stick fill weights are checked during the run.

Low-dose multi-compound blends

Alisol C can be added at trace level to blends of other alisols. A stepwise dilution plan and an HPLC assay of the finished blend show that the compound has reached the intended level, and the result is recorded for each production lot.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.