Oxyresveratrol 98%

Found in the branches of the white mulberry, oxyresveratrol is isolated here from the stem of Morus alba by solvent extraction and purification. It is a stilbene with four hydroxyl groups, and it is a close but distinct relative of resveratrol, with an extra hydroxyl on one ring that changes how it dissolves and how it reacts.

The primary grade is 98% oxyresveratrol by HPLC, in Food / Dietary Supplement Grade. The off-white powder is slightly soluble in water. It is used where the single stilbene, and not a mixed mulberry extract, is the defined ingredient, and the plant part matters as much as the species.

SKU: BOT-PHY-0034 Category: Phytochemicals Tags: Bark & Stem, Mulberry, Plant Compounds, Polyphenols, Solvent Extracted, Stilbenes

Oxyresveratrol Chemical Identity

Oxyresveratrol has the molecular formula C14H12O4 and a molecular weight of 244.2. The skeleton is two benzene rings joined by an ethene bridge in the trans arrangement. One ring carries hydroxyl groups at positions 2 and 4, and the other at 3′ and 5′, which gives the systematic pattern 2,4,3′,5′-tetrahydroxystilbene. Resveratrol has the same skeleton with one fewer hydroxyl, and piceatannol has the same formula as oxyresveratrol with the hydroxyls placed differently, so the three are easily confused by name.

The natural source is the stem, the twigs and branches, of Morus alba L., the white mulberry. In the plant a large share of the stilbene is stored as glycosides, with mulberroside A as the best-known example, and the free compound is released by hydrolysis during processing. The same tree gives other products that are defined by different parts and different chemistry: Morin 98%, Mulberry Leaf Extract 1–5% DNJ and the 10:1 Mulberry Fruit Extract Powder. Leaf and fruit are not the source of oxyresveratrol here, so a buyer should not read those pages as describing this material.

The part is part of the identity. Oxyresveratrol is concentrated in the woody tissue and the root bark of the tree, while the leaf holds an alkaloid and the fruit holds anthocyanins, and each is a separate commercial raw material.

Typical Specifications

Specification Item	Product Information
Natural Source	Morus alba stem
Plant Part	Bark & Stem
Processing	Solvent Extraction & Purification
Compound Class	Polyphenols
Chemical Name (IUPAC)	4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
CAS Number	29700-22-9
Molecular Formula	C14H12O4
Molecular Weight	244.24
PubChem CID	5281717
InChIKey	PDHAOJSHSJQANO-OWOJBTEDSA-N
SMILES	C1=CC(=C(C=C1O)O)/C=C/C2=CC(=CC(=C2)O)O
Purity	98% (HPLC)
Grade	Food / Dietary Supplement Grade
Appearance	Off-White powder
Solubility / Dispersibility	Slightly Soluble in Water
Quality Parameters
Moisture (LOD)	≤5.0%
Total Ash	≤5.0%
Heavy Metals	Lead ≤2 ppm · Arsenic ≤1 ppm · Cadmium ≤1 ppm · Mercury ≤0.1 ppm
Microbiology	TPC ≤1,000 cfu/g · Yeast & Mold ≤100 cfu/g · E. coli Negative · Salmonella Negative/25 g
Shelf Life	24 months in unopened original packaging, cool and dry storage

Oxyresveratrol Purity Grades & Impurities

The 98% figure is an HPLC result that compares the oxyresveratrol peak with the other detected peaks, with detection near the wavelength where the stilbene chromophore absorbs. It leaves out water, ash and any component that does not absorb, so the moisture and ash limits in the table are needed beside it. The grade is a single level for this product.

The main related substances are the stilbenes that travel with it. Resveratrol and its glucoside, piceid, can appear in small amounts, and the glycoside mulberroside A indicates incomplete hydrolysis. The cis isomer forms when the trans compound is exposed to light and elutes earlier than the main peak, so a sample left in strong light can show a growing neighbor that was not in the original powder. Prenylated flavonoids and Diels–Alder type adducts, which are characteristic of mulberry wood, may be present at trace level before purification.

Positional isomers need care. Piceatannol and oxyresveratrol share the formula and the molecular weight, and a method that relies on mass alone cannot tell them apart, so retention time against a reference standard and the ultraviolet spectrum are used for identity. Oxidation is the stability concern, because the resorcinol-type rings darken in air and alkali. A clean lot is off-white to pale cream, and a brown tint is a sign of oxidation or of residual wood pigment.

Plant-derived and synthetic oxyresveratrol share the same main peak. The source statement and the impurity profile therefore matter, since wood-derived material carries mulberry companions and a synthetic route carries reaction by-products.

Oxyresveratrol Solubility & Delivery

Oxyresveratrol is slightly soluble in water, more so than resveratrol, because the additional hydroxyl group raises polarity. It dissolves in ethanol, methanol, acetone and dimethyl sulfoxide, and in dilute alkali, where it also begins to degrade. The solid is moderately crystalline, and dissolution is slow in cold water, so formulators warm the water or pre-dissolve the powder in a small volume of ethanol or glycol.

Delivery depends on protecting the stilbene from light and oxygen. Opaque packaging, nitrogen-flushed containers and an antioxidant in the carrier slow the loss of the trans form. Cyclodextrin complexes and lipid or surfactant systems are described in the literature to raise dispersion. Because the compound isomerizes in light, process steps carried out under white light shorten the life of the batch, and amber glass or filtered lighting is used for solutions. In dry blends the powder is stable if sealed and kept dry, though static can complicate weighing of small amounts.

Application Areas

Capsules With Light-Shielding Shells

Capsules take oxyresveratrol at small weight. The fine off-white powder clings to scoops through static, so anti-static tools, a flow agent and a two-step premix with a dry carrier give a uniform fill, and opaque capsules shield the trans form.

Light-Protected Drink Concentrates

Concentrates dissolve the stilbene in warm water or a small volume of ethanol and glycol. Fill into amber or opaque containers, minimize headspace, and keep the pH mildly acidic, because alkaline bases darken the liquid within hours.

Metal-Aware Tablet Blends

Tablets press oxyresveratrol with a dry binder and a lubricant. Trace metals in some fillers speed discoloration, so a compatibility trial of the full blend with a week of storage under light shows early color change before scale-up.

Complex and Carrier Systems

Cyclodextrin and lipid complexes are used to raise dispersion of the stilbene. The complex is built in a solvent step, dried and milled under low light, and a retained sample from each lot lets the formulator compare dissolution and color on repeat.

Stilbene Comparison Blends

Formulators studying hydroxylation patterns use oxyresveratrol beside resveratrol to compare dissolution and stability. Each ingredient is weighed on its own, the premix is built in steps, and the HPLC trace of the blend confirms that the cis form has not grown during mixing.

Packaging & Commercial Supply

Essencefield supports product evaluation, formulation trials, commercial orders, and ongoing ingredient supply. Packaging, storage, and shipping arrangements are determined by product characteristics, order quantity, stability requirements, and destination-market needs.

Supply Item	General Information
Sample	Available upon request for formulation, testing, and supplier evaluation
Order Quantities	100 g · 1 kg · 5 kg · 25 kg · 100 kg · 500 kg · Bulk
Sample Lead Time	Typically 5–7 days after sample confirmation
Production Lead Time	Typically 15–30 days after order and specification confirmation
Packaging	Suitable protective inner packaging with bags, cartons, drums, or other appropriate outer packaging
Storage	Store in tightly sealed, suitable protective packaging in a cool, dry environment. Protect from moisture, heat, and direct sunlight. Specific storage conditions follow the approved product specification.
Documentation	COA · Product Specification · TDS · SDS · Applicable declarations (as applicable)

Final order quantities, lead times, packaging, documentation, and shipping arrangements are confirmed according to the selected product and commercial requirements.